Multiple myeloma is an incurable cancer characterized by a proliferation of plasma cells in the bone marrow. The disease is associated with substantial morbidity and mortality, and predominantly affects older patients. There is an unmet need for more accessible treatments.
Multiple myeloma is an incurable malignant plasma cell disorder, characterized by clonal proliferation of plasma cells in the bone marrow and the. The disease predominantly affects older patients, with a median age for onset of disease of 72 years. These patients often have many comorbidities and consequently receive multiple concomitant medications.
Most patients with multiple myeloma have symptoms that reduce quality of life, including bone pain, fatigue, anemia, and infections. Patients may have symptom-free periods, but the disease always relapses, and eventually become refractory to all available treatment options due to new mutations of the tumor cells.
Incidence of Multiple Myeloma
Multiple myeloma is an incurable blood cancer. Symptoms like bone pain, fatigue, and infections severely reduce quality of life. Despite advances in treatment, most patients eventually relapse and become resistant to all available therapies, creating a critical need for innovative options.
Unmet Medical Need
The introduction of new drugs during the last decade has improved treatment outcomes. However, multiple myeloma is ultimately fatal, with a 5-year survival around 50 % (SEER.cancer.gov 2019).
Patients with relapsed disease can respond to subsequent therapies, but the duration of response decreases with successive relapses until resistance is developed.
Treatment of relapsed, refractory multiple myeloma (RRMM) is challenging, since patients have continuing symptoms, complications, and decreased quality of life. The patients receive a therapy until the next relapse, or the development of intolerable toxicity and then move on to the next treatment option.
Treatment of Multiple Myeloma
The treatment goal is ultimately to control disease progression and prolong survival. The major drug classes include steroids, proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies. Recently, four new classes have been approved for use in triple-class refractory patients: BCMA-targeting antibody conjugates, selective inhibitors of nuclear export, anti-BCMA CAR-T cells and bispecific antibodies.
Triple-class refractory patients have a disease that is refractory to immunomodulatory drugs, proteasome inhibitors, and CD38-targeting monoclonal antibodies. The patients have a poor prognosis with a very short expected survival measured in months.
None of the newly approved medicinal products has provided a cure. Ultimately patients relapse and treatment options are exhausted. There is a continued unmet need, particularly in elderly patients who require additional available treatment options.
Pepaxti®
Melflufen is the first treatment of its kind, developed to deliver cancer-killing agents directly inside multiple myeloma cells. It uses enzymes in these cells to activate and release its active substance, damaging cancer DNA and helping to stop disease progression.